Vaccine Research and Development, Pfizer Inc., Pearl River, NY 10965, USA. By analogy to successful vaccine antigen engineering approaches for other viral pathogens, the high-resolution prefusion gB structure provides a basis to develop stabilized prefusion gB HCMV vaccine antigens. Línea Ilimitada 8 GB Solo para clientes miMovistar, Fusión, Conecta Max y tarifas de contrato ¡15 de dto 5 meses Datos y Voz Ilimitados Velocidad 5G 8 GB Servicios Adicionales Conexión Segura Movistar Cloud 7,90 6,50/mes IVA incl. The structure rationalizes known gB antigenic sites. Our results revealed the structural rearrangements that mediate membrane fusion and details of the interactions among the fusion loops, the membrane-proximal region, transmembrane domain, and bound fusion inhibitor that stabilized gB in the prefusion state. We stabilized prefusion gB on the virion with a fusion inhibitor and a chemical cross-linker, extracted and purified it, and then determined its structure to 3.6-Å resolution by electron cryomicroscopy. HCMV glycoprotein B (gB) transitions irreversibly from a metastable prefusion to a stable postfusion conformation to fuse the viral envelope with a host cell membrane during entry. Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity. 128 GB, Non Expandable Dual SIM: Nano + Nano Supported in India VoLTE. ![]()
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